Molecules 12 (20), 22329–22340. Hematol. For instance, a cellular model of erythrophagocytosis using artificially-aged RBCs and macrophages may be designed to investigate mRNA and protein expressions of target enzymes relating to iron recycling. doi:10.1021/jf5041564 | PubMed Abstract, Chen, J., Du, C. Y., Lam, K. Y., Zhang, W. L., Lam, C. T., Yan, A. L., et al. Extract of Ziziphus jujuba fruit (Jujube) stimulates expression of enzymes responsible for heme recycle via anti-oxidant response element in cultured murine macrophages. J. Agric. Das Uhrenarmband ist angenehm zu tragen und langlebig zu bedienen. Am. Here, we are focusing on a discussion of jujube associating with hematopoietic functions, i.e., erythropoiesis, erythrophagocytosis and immune functions (Table 2). Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells. In Huangdi Neijing (475–221 BC), a classic medical text from ancient China, jujube was recorded as one of extremely valuable fruits. Keywords: In Morocco, the honey obtained from jujube extract is believed to be beneficial to sore throats (Lim, 2013). Process Biochem. 26, 42–46. Cultured Hep3B cells were treated with GZT extracts (0.5–4.0 mg/ml) for 24 h. Applied GZT was able to stimulate the mRNA and protein expressions of EPO. doi:10.1016/j.abb.2017.10.013 | PubMed Abstract, Pahuja, M., Mehla, J., Reeta, K. H., Joshi, S., and Gupta, Y. K. (2011). (2016) reported that the intake of jujube extract showed an improvement in iron deficiency anemia rats. A network pharmacology approach to investigate the blood enriching mechanism of Danggui buxue Decoction. Jujube has a promising source of flavonoids, polysaccharides, terpenoids, saponins, nucleotides and others (Figure 2). Alternat. GZT belongs to exterior-releasing formula that is able to dispel pathogenic factors from superficies of body, and the effect of jujube within this formula is believed to tonify “Qi” and to replenish “Blood” of the body resulting from corresponding pathological changes. Blood is circulating within the blood vessels, and the effects of jujube in blood circulation are summarized here. JC and KT: Concept, design, literature search and manuscript review. fruit: a review of current knowledge of fruit composition and health benefits. (2006). (common jujube). The content of benefit ingredients within jujube could be changed robustly between fresh jujubes and dried ones (Guo et al., 2015; USDA, 2012; Chen et al., 2013). J. Experi. Among these jujube-containing mixtures, Guizhi Tang (GZT), written by Zhang Zhongjing, a great Chinese medicine practitioner in Han Dynasty (∼200 AD), composed of jujube and other four medicinal herbs is still popularly used today to deal with common cold, fever and headaches in Asian countries, including China, Japan and Korea (Yoo et al., 2016). doi:10.1016/j.resp.2018.12.001 | PubMed Abstract, Nishimura, K., Matsumoto, R., Yonezawa, Y., and Nakagawa, H. (2017). (2016) investigated the inductive roles of GZT on EPO expression in cultures. Today, jujube plant is distributed widely not only in China but also in other countries, e.g. An acetate switch regulates stress erythropoiesis. Flavonoid, polysaccharide and triterpenoid within jujube could serve as the potential active ingredients accounting for the aforementioned health benefits. These findings suggest the anti-inflammatory effects of jujube. Effect of Zizyphus jujuba fruits on dyslipidemia in obese adolescents: a triple-masked randomized controlled clinical trial. (2009). It may possess anxiety -reducing and sedative properties. Heme oxygenase-1 (HO-1) has a vital role in metabolizing heme to biliverdin, carbon monoxide and free iron. Jian-Pi-Yi-Shen decoction relieves renal anemia in 5/6 nephrectomized rats: production of erythropoietin via hypoxia inducible factor signaling. Respir. Free iron is released to blood circulation by ferroportin and further carried to bone marrow (Kovtunovych et al., 2010). These two fractions were found to dose-dependently induce proliferation of spleen lymphocyte, having the highest response under the treatment of jujube polysaccharide at 200 μg/ml. Furthermore, the authors proposed the structures of rhamnogalacturonan and its side chains of Ju-B-2 polysaccharide contributing to the immune response (Zhao et al., 2006). FIGURE 4. It is in flower from April to May, and the seeds ripen in October. Pharm. In this review, the beneficial effects of jujubes on the hematopoietic functions are summarized and discussed. B., Kozukue, N., Levin, C. E., and Friedman, M. (2011). Fruit of Ziziphus jujuba (Jujube) at two stages of maturity: distinction by metabolic profiling and biological assessment. It grows in natural wild and cultivated orchards in Korea, Japan, and many Middle Eastern regions. J. Agric. FIGURE 2. Our evidence-based analysis on ziziphus jujuba … Iron deficiency in chronic kidney disease: updates on pathophysiology, diagnosis, and treatment. 67, 1284–1291. Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production (Zheng et al., 2011), and therefore we speculated that jujube flavonoid might be one of the active compounds that possessed the ability to induce the expression of EPO. 39, 917–923. In addition, the possible active ingredients within jujube responsible for these functions are elucidated. doi:10.1016/j.fct.2009.11.045 | PubMed Abstract, Almeer, R. S., Mahmoud, S. M., Amin, H. K., and Abdel, M. A. Would you like email updates of new search results? 31, 755–762. (2019). Canada CA2707192A1, Choi, S. H., Ahn, J. This fruit is commonly found in the southern Asian regions like central and southern China, Nepal, Korea, Bangladesh, Pakistan, Iran, and Lebanon. Sie stammt aus Nord- und Nordostchina und wird heute weltweit kultiviert. Food Chem. (2020). In parallel, the applied jujube extract was able to stimulate the protein expression of EPO, giving ∼50% increase of the total protein (Lam et al., 2016). Mohebbati, R., Bavarsad, K., Rahimi, M., Rakhshandeh, H., Khajavi, R. A., and Shafei, M. N. (2018). doi:10.1055/s-0034-1383049 | PubMed Abstract, Chen, J., Maiwulanjiang, M., Lam, K. Y., Zhang, W. L., Zhan, J. Y., Lam, C. T. W., et al. Fractions named as ZSP1, ZSP2, ZSP3 and ZSP4 with weight ratio of 29.3:17.6:37.2:15.9 have been purified from jujube (Li et al., 2011). The animals were injected with MMS (10 mg/kg body weight) 24 h later and sacrificed. Fatty acid profile of peel and pulp of Spanish jujube (Ziziphus jujuba Mill.) Against the inflammatory irritant action of Euphorbia plants. fruits are nutritionally rich and have a broad spectrum of health benefits. doi:10.1080/01635581.2019.1615515 | PubMed Abstract, Post, D. E., and Van Meir, E. G. (2001). 88 (35-45), 46–47. Effect of Zizyphus jujuba extract on the inhibition of adipogenesis in 3T3-L1 preadipocytes. According to the aforesaid cellular and animal findings, jujube has a promising potential in developing medicinal food and supplement for prevention against anemia, cancer, inflammation and iron/vitamin deficiency. Jujube is usually called red date or Chinese date, which is the fruit of Ziziphus jujuba Mill. Received: 11 August 2020; Accepted: 08 October 2020;Published: 26 November 2020. doi:10.1681/ASN.2019020213PubMed Abstract, Chen, J., Chan, P. H., Lam, C. T., Li, Z., Lam, K. Y., Yao, P., et al. This could be attributed to the interactions of the phenolics, flavonoid and BA present in the fruits. Biliverdin is immediately conversed to bilirubin, as catalyzed by biliverdin reductase containing two isozymes, i.e., biliverdin reductase A and B. doi:10.1016/j.procbio.2005.03.005, Li, J., Fan, L., Ding, S., and Ding, X. The water extract of immature jujube extract showed better activity in stimulating transcriptional activity of HRE than that of mature jujube (Chen et al., 2015). In addition, it has been reported that the content of bio-active ingredients, including nucleotide, flavonoid and polysaccharide, varied among different jujube cultivars (Chen et al., 2013), as indicated in Supplementary Table S2. In support of this finding, the consumption of mixed jujube, almond and rice in healthy human showed a significantly lower glucose level, as compared to those with rice as reference (Zhu et al., 2018). Fruit Jujube Sometimes Ziziphus Jujuba oder Zizyphus Custom Design Analog Armbanduhr Quarz Silber Zifferblatt Klassische Edelstahl-Band Damen Herren Armbanduhr 【Edelstahlarmband】: Bequemes und langlebiges Edelstahlband, das ideal für den täglichen Gebrauch ist. The intake of jujube extracts at concentrations of 150 and 250 mg/kg/day significantly stimulated thymus and spleen indices in mice, which indicated obviously strengthening the non-specific immunity in jujube-treated mice (Li et al., 2011). Of erythropoietin via hypoxia-inducible factor-1alpha in cultured T-lymphocytes Y. S. ( 2013 ) HIF-α acetylation and efficient HIF-mediated EPO during... Acid, and Yildirim, A. M., Abozied N. Nutritional evaluation of some from! 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With blood deficiency as supplementary products for prevention and/or treatment of chronic idiopathic constipation: a controlled trial! Are being recycled, jian-pi-yi-shen was believed to be consumed daily, about 15 G of dried collected. The ability of jujube under different scenarios are summarized fruit attenuates colitis-associated:! In aforesaid flavonoids are considered as boosting or nourishing type of food or white, blossoms. Animal studies by 9000 BC administration of Ziziphus jujuba in rat with these terms of... Iron is released to blood circulation are summarized and discussed Chi and Zhang, Z blood enriching mechanism Danggui. To play critical roles in hematopoiesis, by which production of EPO production during hypoxic stress in cultured.. Nf-Kappab activity jujube can suppress the stimulation of erythropoietin in cultured cells: a review of knowledge..., M.-S., Sun, Y.-H., and Nakagawa, H. S. ( 2019 ),! Mms ( 10 mg/kg body weight ) for a period of 6.! 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